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This effect is harmless and will disappear when the sulfasalazine intiasta medication is stopped. This medication may decrease the effectiveness of combination-type birth control pills. The others are potential side effects as they have been seen with closely related drugs. Your symptoms may not improve right away when you start taking sulfasalazine, and you may still need your other medications for awhile. This publication has been made possible because of voluntary donations given to the Arthritis Research Campaign. 5-ASA is primarily metabolized in both the liver and intestine to N-acetyl-5-aminosalicylic acid via non-acetylation phenotype dependent route. What happens if overdose? Seek emergency medical attention if you think you have used too much of this medicine.