Rosiglitazone, one of the medicines in AVANDAMET, may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain angina or heart attack myocardial infarction. These trials include total of 14,067 patients treatment groups containing rosiglitazone 6,311, comparator groups 7,756 with patient-year exposure of 21,803 patient-years for rosiglitazone and 25,998 patient-years for comparator. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Hepatic Effects Metformin: Since impaired hepatic function kopen goedkope avandamet geen recept has been associated with some cases of lactic acidosis, AVANDAMET should generally be avoided in patients with clinical or laboratory evidence of hepatic disease. There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with AVANDAMET or any other antidiabetic drug. Given the potential for dose-related adverse events with rosiglitazone, decrease in the dose of rosiglitazone may be needed when gemfibrozil is introduced.