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Some of these cases had neither pre-existing liver disease nor serious underlying medical condition. When itraconazole in plasma is measured by bioassay, values reported may be higher than those obtained by HPLC due to the presence of the bioactive metabolite, hydroxyitraconazole. Whenever possible, plasma concentrations of these drugs should be monitored, and dosage adjustments made after concomitant SPORANOX therapy is initiated. Sporanox capsules are used to treat three types of serious fungal infection: blastomycosis, histoplasmosis, and aspergillosis. Such signs and symptoms may include unusual fatigue, anorexia, nausea and or vomiting, jaundice, dark urine, or pale stools. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. The pharmacokinetics of itraconazole were studied in healthy male volunteers who received, in crossover design, kobe itraconazole ingen recepter single 100-mg doses of itraconazole as polyethylene glycol capsule, with or without full meal.