Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Usually, the daily dose will not be more than 250 milligrams for adults and 200 milligrams for children and teenagers. Children under 15 years of age had significantly lower plasma concentration dose ratios, compared with adults. Drug Abuse and Dependence Anafranil has not been systematically studied in animals or humans for its potential for abuse, tolerance, or physical dependence. MedicineNet provides reliable doctor produced health and medical information. Although the efficacy of Anafranil after 10 weeks has not been documented in controlled trials, patients have been continued in therapy under double-blind conditions for up to year without loss anafranil drogas of benefit. Males may experience sexual dysfunction while taking this medication.
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