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An interaction study with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics. Yahoo! is not an investment adviser and does not provide, endorse or review any information or data contained herein. Cirrhosis, Child-Pugh classification and the mean AUC values of the volunteers with moderate hepatic impairment were 37 higher than in normal subjects, but still within the range seen in subjects without impaired geen recept femara fedex levering function. In human liver microsomes, letrozole strongly inhibited CYP2A6 and moderately inhibited CYP2C19.